Theoretical model of postsynaptic AMPA receptor trafficking during synaptic plasticity


  • Huairui Huang and Yinyun Li


Excitatory synaptic strength is reported to be positively related to the number of AMPARs in postsynaptic domain (PSD), which indeed actively transfer among postsynaptic density, extrasynaptic membrane (ESM), and dendritic cytosol. In this paper a biophysical model is developed to dissect the kinetics of AMPAR trafficking in equilibrium as well as during induction of synaptic plasticity. The analytical solutions are derived for both timescales of AMPAR exocytosisendocytosis and equilibrium distribution of AMPARs. Our model indicates differential roles of transition rates playing in inducing synaptic potentiation or depression, which include rate of AMAPR exocytosis, rate of AMPAR endocytosis, and AMPAR hopping rate between PSD and ESM region. In summary, our work highlights the underlying mechanism for AMPAR trafficking during dynamic equilibrium and synaptic plasticity, and provides mathematical insights that could be learned from to treat neurological diseases related to malfunctions of AMPAR movement.