MDRD or CKD-EPI study equations for estimating prevalence of stage 3 CKD in Moroccan population


  • Malak Snoussi
  • Imane Benzekri, Mouad Sqalli Houssaini, Amina Aazaouzi, Leila Jeddane, Imane Smyej, Mohamed Kettani Halabi, Fatima Azzahra Lahlou


Background: According to the NHANES study, the prevalence of stage 3 chronic kidney disease (CKD) is increasing. The glomerular filtration rate was estimated according to the equation of the MDRD study. More recently, a new estimator has been proposed, the CKD-EPI equation, which is presumed to better perform in normal glomerular filtration rate (GFR) ranges. The aim of the study was to measure the difference in the prevalence of stage 3 CKD in the Moroccan population using equations from the MDRD or CKD-EPI study equations.
Methods: CKD screening was organized in the National Reference Laboratory (LNR) in Casablanca in Morocco. Hospitalized patients or outpatients have been included. GFR was estimated by the MDRD study equation and by the CKD-EPI equations.
Results: The population screened consisted in 29 724 people (54% of male). The prevalence of stage 3 CKD in this population using the MDRD or the CKD-EPI equations was 27.1% and 26.3%, respectively. The prevalence of stage 3 CKD is significantly higher with the MDRD study equation (p < 0.001). Conclusion: Following the method used for estimating GFR, MDRD or CKD-EPI study equations, prevalence of stage 3 CKD varies in a Moroccan population. These differences are significantly important and must be confirmed and explained by additional studies using GFR measured with a reference method.