Unravelling the refolding of membrane proteins, one of the most challenging therapeutic targets

Abstract

Being involved in many essential cellular processes, Membrane Proteins (MPs) constitute one of the most important therapeutic targets, such as G protein-coupled receptors (GPCR), small molecule transporter or ion channels [1-3]. A detailed knowledge of their structure and activity is essential to design new therapeutic or biomimetic agents and therefore plays a significant role in the drug discovery process.